• Publications

    Hundley Lab Publications

    Dhakal A, Salim C, Skelly M, Amichan Y, Lamm AT and Hundley HA (2024) ADARs regulate cuticle collagen expression and promote organismal survival to pathogen infectionBMC Biology, 2024 Feb 16;22(1):37. PDF


    Mahapatra A, Dhakal A, Noguchi A, Vadlamani P and Hundley HA (2023) ADAR-mediated regulationof PQM-1 expression in neurons impacts gene expression throughout C. elegans and regulates survival from hypoxia. PLOS Biology, 2023 Sep 25;21(9):e3002150. PDF


    Raghava Kurup R, Oakes EK, Vadlamani P, Nwosu O, Danthi P and Hundley HA (2022) ADAR3 activates NF-kB signaling and promotes glioblastoma cell resistance to temozolomide, Scientific Reports, 2022 Aug 3;12(1):13362. doi: 10.1038/s41598-022-17559-4. PDF


    Raghava Kurup R, Oakes EK, Manning AC, Mukherjee P, Vadlamani P and Hundley HA (2022) RNA binding by ADAR3 inhibits adenosine-to-inosine editing and promotes expression of the immune response protein MAVS, JBC, 2022 Jul 15;102267. doi: 10.1016/j.jbc.2022.102267. PDF


    Erdmann EA, Abraham O and Hundley HA (2022) Caenorhabditis elegans expressing a Vitellogenin::GFP fusion protein show reduced embryo content and brood size, Micropublication Biology, 2022Mar 1;2022:10.17912/micropub.biology.000532.


    Mukherjee P*, Raghava Kurup R* and Hundley HA (2021) RNA immunoprecipitation to find targets of RNA modification enzymes, Methods in Enzymology: RNA Modification Enzymes, 2021;658:137-160.


    Erdmann EA, Mahapatra A, Mukherjee P, Yang B and Hundley HA (2021) To protect and modify double-stranded RNA – the critical roles of ADARs in development, immunity and oncogenesis. Critical Reviews in Biochemistry and Molecular Biology, 2021 Feb; 56(1):54-87. PDF


    Rajendren S, Dhakal A, Vadlamani P, Townsend J, Deffit SN and Hundley HA (2021) Profiling neural editomes reveals a molecular mechanism to regulate RNA editing during development. Genome Research, 2021 Jan;31(1):27-39. PDF


    Arribere JA, Kuroyanagi H and Hundley HA (2020) mRNA editing, processing and quality control in Caenorhabditis elegans, Genetics, 2020 Jul;215(3):531-568. PDF


    Ganem NS, Ben-Asher N, Manning AC, Deffit SN, Washburn MC, Wheeler EC, Yeo GW, Zgayer O B-N, Mantsur E, Hundley HA, Lamm AT (2019) Disruption in A-to-I editing levels affects C. elegans development more than a complete lack of editing, Cell Reports, 2019 Apr 23;27(4):1244-1253.


    Oshiro RT, Rajendren S, Hundley HA, Kearns DB (2019) Robust Stoichiometry of FliW-CsrA Governs Flagellin Homeostasis and Cytoplasmic Organization in Bacillus subtilis, mBio, 2019 May 21;10(3).


    Rajendren S, Manning AC, Al-Awadi H, Yamada K, Takagi Y, Hundley HA (2018) A Protein-Protein Interaction Underlies the Molecular Basis for Substrate Recognition by an Adenosine to Inosine RNA Editing Enzyme, NAR, 2018 Oct 12;46(18):9647-9659.


    Deffit SN, Yee BA, Manning AC, Rajendren S, Vadlamani P, Manning AC, Wheeler EC, Domissy A, Washburn, MC, Yeo GW, Hundley HA (2017) The C. elegans neural editome reveals an ADAR target mRNA required for proper chemotaxis, eLife, 2017 Sep 19;6. pii: e28625. doi: 10.7554/eLife.28625.


    Oakes E, Vadlamani and Hundley HA (2017) Methods for the Detection of Adenosine-to-Inosine Editing Events in Cellular RNA, Methods in Molecular Biology, volume 1648: mRNA Processing, 2017;103-127. doi: 10.1007/978-1-4939-7204-3_9.


    Oakes E, Anderson, Cohen-Gadol A, Hundley HA (2017) Adenosine Deaminase that Acts on RNA 3 (ADAR3) Binding to Glutamate Receptor Subunit B Pre-mRNA Inhibits RNA Editing in Glioblastoma, JBC, 2017 Mar 10; 292(10):4326-4335.


    Washburn MC and Hundley HA (2016) Trans and cis factors affecting A-to-I RNA editing efficiency of a noncoding editing target in C. elegans, RNA, 2016 Feb 25.


    Deffit SN and Hundley HA (2016) To edit or not to edit: Regulation of ADAR editing specificity and efficiency, WIREs RNA, Jan-Feb;7(1):113-27. doi:10.1002/wrna.1319.

    • One of the top 10 Accessed Articles in WIREs RNA for 2016

    Washburn MC and Hundley HA (2016) Controlling the editor: the many roles of RNA binding proteins in regulating A-to-I RNA editing, Advances in Experimental Medicine and Biology, volume 907: RNA Processing, 2016;907:189-213. doi:10.1007/978-3-319-29073-7_8.


    Wheeler EC, Washburn MC, Major F, Rusch DB, Hundley HA (2015) Noncoding regions of C. elegans mRNA undergo selective adenosine to inosine deamination and contain a small number of editing sites per transcript, RNA Biology, 2015 Feb;12(2):162-74. doi:10.1080/15476286.2015.1017220.


    Washburn MC, Kakaradov B, Sundararaman B, Wheeler E, Hoon S, Yeo GW, and Hundley HA (2014) The dsRBP and inactive editor, ADR-1, utilizes dsRNA binding to regulate A-to-I RNA editing across the C. elegans transcriptome, Cell Reports, Feb 27;6(4):599-607.

    Hundley HA (2013) Regulation of gene expression through inosine-containing UTRs, In RNA Editing: Current Research and Future Trends, S. Maas, ed. (Horizon Press)


    Bass B, Hundley H, Li JB, Peng Z, Pickrell J, Xiao XG, Yang L. (2012) The difficult calls in RNA editing, Nature Biotechnology, Dec 7;30(12):1207-9.


    Capshew CR, Dusenbury KL and Hundley HA (2012) Inverted Alu dsRNA structures do not affect localization but alter translation of human mRNAs independent of RNA editing, Nucleic Acids Research (NAR), 2012 Sep 1;40(17):8637-45.


    Hundley HA and Bass BL (2010) RNA editing in double-stranded UTRs and other noncoding RNA sequences, TiBS, 2010 Jul;35(7):377-83.


     Before Coming to IU

    Hundley HA, Krauchuk AA, Bass BL (2008) C. elegans and H. sapiens mRNAs with edited 3’ UTRs are present on polysomes, RNA, 2008 Oct;14(10):2050-2060.


    Bass BL, Hellwig S, Hundley HA. (2005) A nuclear RNA is cut out for Translation, Cell, 2005 Oct21;123(2):181-183.


    Rauch T, Hundley HA, Pfund C, Wegrzyn RD, Walter W, Kramer G, Kim SY, Craig EA, Deuerling E (2005) Dissecting functional similarities of ribosome-associated chaperones from Saccharomyces cerevisiae and Escherichia coli, Molecular Microbiology, 2005 Jul;57(2):357-65.


    Hundley HA, Walter W, Bairstow S, Craig, EA. (2005) Human Mpp11 J-protein: Ribosome-tethered Molecular Chaperones Are Ubiquitous, Science, 2005 May 13; 308(5724):1032-4.


    Craig EA, Eisenman HE, Hundley HA. (2003) Ribosome-tethered molecular chaperones: the first line of defense against protein misfolding? Current Opinion in Microbiology 2003 Apr; 6(2):157-62.


    Hundley H, Eisenman H, Walter W, Evans T, Hotokezaka Y, Wiedmann M, Craig E. (2002) The in vivo function of the ribosome-associated Hsp70, Ssz1, does not require its putative peptide-binding domain. Proc Natl Acad Sci 2002 Apr 2;99(7):4203-8.