We are interested in deciphering RNA-based mechanisms of gene regulation and connecting that knowledge to impacts on organismal physiology and disease. Our studies are centered on a conserved family of proteins, called ADARs, which can affect gene expression through RNA binding and RNA modification. To investigate important molecular mechanisms of ADARs, we use a variety of genetic, biochemical, bioinformatic and molecular biology approaches in both the model organism, Caenorhabditis elegans, and human cell lines (particularly glioblastoma).